Acute rejection episodes in pediatric renal transplant recipients with cytomegalovirus infection – kranz – 2007 – pediatric transplantation – wiley online library

Abstract: CMV infection is the most important opportunistic virus infection after renal transplantation leading to increased patient mortality, graft loss, risk for acute rejection episodes and impaired renal function. Bone marrow biopsy test results The potential impact of prophylactic anti-viral therapy on long-term graft outcome is relevant. Bone marrow blood cancer The aim of this study was to evaluate the incidence of CMV infection, its risk factors and long-term outcome in children after renal transplantation.


Procedure for bone marrow biopsy 103 children (mean age 10.6 ± 5.3, range 1.6–22.0 yr) were monitored weekly for pp65 for the first 6–8 wk after renal transplantation, followed by a monthly monitoring for the first year. Does a bone marrow transplant hurt CMV infection occurred in 23/103 children (21.1%) with 10 patients (9.7%) developing CMV disease characterized by positive pp65 in the presence of organ involvement. Bone marrow transplant cost in usa The CMV R?/D+ and R+/D+ serostatus was significantly associated with an increased risk of CMV infection (p < 0.0001 and p = 0.009). Composition of bone marrow 14/28 R?/D+ patients developed CMV infection despite prophylactic treatment with CMV hyperimmune globulin. Bone marrow production The incidence of acute rejection episodes after or during CMV infection was significantly increased (p = 0.003) and the D+ serostatus was significantly associated with acute rejection episodes within the first year after transplantation (p = 0.006). Why donate bone marrow In summary the overall incidence of CMV infection in this single center experience is 21.1%. Bone marrow red blood cells The D+ serostatus represents a serious risk factor for both CMV infection and acute rejection episodes. Purpose of red bone marrow In future the potential impact of different modalities of prophylactic anti-viral therapy on the prevention of acute rejection should be considered.

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