Basic heart failure research _ university of wisconsin – department of medicine

Basic research studies in the division are supported by five federally funded R01 grants with additional awards and private funding. The symptoms of heart disease A variety of chronic HF and hypertrophy models are routinely used in these investigations, including the canine tachycardia pacing-induced dilated cardiomyopathy model, infarct models (murine rat, rabbit or canine), pressure overload models (mouse, rat and rabbit) and transgenic mouse models. Rheumatic heart disease ecg In addition, seminal findings in the animal models are confirmed in human failing cardiac muscle obtained in collaboration with UW heart transplant surgeon, Robert B. Coronary heart disease cure Love.


Calcineurin signaling in cardiac hypertrophy – Cardiac hypertrophy is an adaptive mechanism by the heart to various stimuli including exercise, hypertension, sarcomeric mutations, myocardial infarctions, and growth factor overstimulation. Heart disease cure The hypertrophic response is frequently followed by dilation and heart failure. What is considered heart disease Many of these hypertrophic stimuli appear to involve calcium and calcineurin signaling. Exercise and heart disease Recent experiments by Kaji and investigators in his lab have revealed that two murine models of hypertrophy, thyroxin overstimulation and myosin binding protein C deletion, both involve calcineurin signaling. Symptoms heart disease Current work focuses on defining the molecules involved in this signaling cascade.

Electrical remodeling in the failing heart – Investigations led by Jonathan Makielski have revealed a persistent inward Na+ current which contributes to the prolonged action potential in failing myocytes. Alcohol heart disease The proarrhythmic effect of this current can contribute to the high risk of sudden death in patients with HF. Coronary heart disease epidemiology Studies are continuing to characterize this current and its regulation. Describe heart disease Complementary investigations on the L-type Ca2+ channel lead by Timothy J. Coronary artery disease youtube Kamp and Roberto Coronado (Physiology) demonstrate that this channel is half as abundant in failing myocytes from the canine tachycardia pacing model. Rheumatic heart disease pathology In addition, currents through these channels decay more slowly, contributing to the prolonged action potential noted in HF. Congenital heart disease surgery This loss of L-type Ca2+ channels contributes to the abnormalities of excitation-contraction coupling and contractile dysfunction.

Embryonic stem cell-derived cardiomyocytes – Pioneering studies by James A. Hypertensive heart disease treatment Thomson (Primate Research Center) have produced pluripotent embryonic stem cells from rhesus monkeys as well as humans. Chronic ischemic heart disease Timothy J. Coronary heart disease prevention Kamp, in collaboration with Thomson, is characterizing embryonic stem cell-derived cardiomyocytes. Types of heart disease in humans This unique cell system provides opportunities for important research. Heart disease description The cardiomyocytes also represent a promising future therapeutic approach to replace diseased heart myocytes.

Myocardial energy metabolism and exercise intolerance in heart disease – The Saupe laboratory’s current research has two main components. Ischemic heart disease definition The first is the study of myocardial energy metabolism; how it changes with normal aging, exercise training, and diseases such as heart failure, diabetic cardiomyopathy and ischemic heart disease. Congenital heart disease echocardiography The overall goal of this research is to improve understanding of the biochemistry of myocardial metabolism, allowing therapeutic manipulation of myocardial metabolism. Left main coronary artery disease symptoms We are particularly interested in investigating the mechanism(s) by which increasing the amount of glucose and insulin provided to the ischemic heart is cardioportective. Heart disease symptons We also focus on an important enzyme in maintenance of cardiac energy stores, AMP-activated protein kinase. Valvular heart disease icd 9 In additions, other research investigates the causes of exercise intolerance in heart disease. Congenital heart disease asd These studies investigate the molecular and biochemical mechanisms of exercise intolerance in animal models of heart failure of varying etiologies. Congenital heart disease prognosis Upon determining contributing causes to exercise intolerance, the major goal is to develop targeted pharmacological and non-pharmacological interventions that may improve exercise tolerance. Rheumatic heart disease emedicine The experimental models we use are primarily rat models of acute and chronic heart failure, as well as young and old transgenic and wild type mice.

Myofibrillar function in heart failure – Matthew R. Congenital heart disease evolve case study Wolff and Richard L. Coronary heart disease tests Moss (Physiology) have demonstrated that myofilaments from failing canine and human hearts exhibit increased Ca2+ sensitivity due to decreased basal phosphorylation. Coronary heart disease vs ischemic heart disease These results provide an explanation for some of the contractile dysfunction observed in failing myocytes. Coronary heart disease hereditary The dynamic nature of these alterations in myofibrillar function during the cardiac cycle is under continued investigation.

Neurohormonal regulation of excitation-contraction coupling in heart failure – A variety of studies examining the molecular mechanisms of beta-adrenergic dysregulation of various proteins involved in excitation-contraction coupling including the L-type Ca2+ channel, the Ca2+ release channel of the sarcoplasmic reticulum, and myofilament proteins are being investigated by Timothy J. Congenital heart disease medscape Kamp, Matthew R. Congenital heart disease mayo clinic Wolff, Johannes Hell (Pharmacology), Richard L. Coronary heart disease diet plan Moss and Hector Valdivia (Physiology). Coronary heart disease recipes This work has demonstrated altered phosphorylation status of these proteins and is dissecting the molecular details underlying these changes.

Sleep disordered breathing in heart failure – Jerome A. Heart disease names Dempsey (Preventive Medicine) and Matthew R. Rheumatic heart disease ppt Wolff collaborate in investigating the role of sleep disordered breathing in the progression of HF in the canine tachycardia pacing dilated cardiomyopathy model and in patients with advanced HF. Meaning of heart disease Therapies to prevent the transient hypoxemia associated with this disordered breathing are showing promise.

Transverse tubular system remodeling in heart failure – Efforts led by Timothy J. Signs of heart disease in fingernails Kamp, Roberto Coronado (Physiology), Matthew R. Ischemic heart disease nhs Wolff, Robert A. Heart disease prevention Haworth (Surgery), and Hector Valdivia recently revealed that the transverse tubular system in failing canine ventricular myocytes is dramatically decreased. How to get a heart disease Since the T-tubules are where excitation-contraction coupling is normally initiated, remodeling of this system plays a critical role in producing the contractile dysfunction in failing muscle. Valvular heart disease ppt Further studies are underway characterizing the alterations in the proteins involved in excitation-contraction coupling and Ca2+ cycling as a result of T-tubule loss.

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