Bone marrow suppression – wikipedia

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Bone marrow suppression or myelotoxicity (adjective myelotoxic) or myelosuppression is the decrease in production of cells responsible for providing immunity ( leukocytes), carrying oxygen ( erythrocytes), and/or those responsible for normal blood clotting ( thrombocytes). Yellow bone marrow contains [1] Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. Adult bone marrow [2] The risk is especially high in cytotoxic chemotherapy for leukemia.

Non-steroidal anti-inflammatory drugs, in some rare instances, may also cause bone marrow suppression. Color of bone marrow The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). Bone marrow donor list Instead, the drugs affect new blood cells that are being made by the bone marrow. What is bone marrow edema [3] When myelosuppression is severe, it is called myeloablation. Bone marrow biopsy kit [4]

Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. How do you donate bone marrow This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.

Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. What is bone marrow depression In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. Lack of bone marrow [5]

Thiazide diuretics can also lead to bone marrow suppression as an adverse effect.

Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn’s disease. Location of yellow bone marrow Chemotherapy induced myelosuppression [ edit ]

Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection. Success of bone marrow transplant [ citation needed]

G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. Bone marrow donation surgery [6] [7]

GM-CSF has been compared to G-CSF as a treatment of chemotherapy-induced myelosuppression/ Neutropenia. Bone marrow donor payment [8] Prediction [ edit ]

In developing new chemotherapeutics, the efficacy of the drug against the disease is often balanced against the likely level of myelotoxicity the drug will cause. Bone marrow transplant engraftment In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. Bone marrow transplant history [9] These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. Bone marrow disease names See also [ edit ]

• ^ Azathioprine side effects Archived November 25, 2010, at the Wayback Machine.

• ^ “Researchers urge monitoring of bone health during chemotherapy”.

• ^ Hirbe AC, Uluckan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher K (April 2007). What is bone marrow disease “Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner”. Yellow bone marrow stores Blood. Video of bone marrow biopsy 109 (8): 3424–31. Symptoms of bone marrow cancer doi: 10.1182/blood-2006-09-048686. Bone marrow transplant survival rate PMC 1852257 . Bone marrow transplant youtube PMID 17192391.

• ^ Beveridge RA, Miller JA, Kales AN, et al. White blood cells in bone marrow (1998). Purpose of bone marrow “A comparison of efficacy of sargramostim (yeast-derived RhuGM-CSF) and filgrastim (bacteria-derived RhuG-CSF) in the therapeutic setting of chemotherapy-induced myelosuppression”. Bone marrow loss Cancer Invest. Role of bone marrow 16 (6): 366–373. What is the function of bone marrow doi: 10.3109/07357909809115775. A bone marrow biopsy PMID 9679526.

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