Cancer treatments may harm the heart – harvard health

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Doctors strive to prevent the cure for one disease from causing another.

Cancer treatment can be the proverbial double-edged sword. Coronary heart disease diagnosis Radiation therapy and chemotherapy are increasing the number of people who survive cancer. Exercise heart disease However, they can also cause these same people to develop cardiovascular disease.

Radiation therapy can cause heart attack, heart failure, and arrhythmias. Heart disease symptoms women Traditional and novel chemotherapy agents can damage the heart or peripheral blood vessels, or cause problems with clotting or blood lipids. Coronary artery disease journal articles Some serious cardiovascular effects occur while the chemotherapy is being given; others appear long after cancer has become a distant memory.

“Almost every chemotherapy drug has some effect on the cardiovascular system, and most are not good. Hypertensive heart disease icd 9 But with the new anticancer agents, an increasing amount of cardiac toxicity is being observed,” says Dr. Diabetes and heart disease Mandeep R. Congenital heart disease can be corrected with Mehra, executive director of the Center for Advanced Heart Disease at Brigham and Women’s Hospital and a professor at Harvard Medical School.

The list of undesirable effects caused by a growing inventory of antitumor agents has overwhelmed the ability of cardiologists and medical oncologists to keep pace with heart-protection strategies. Heart disease in dogs As a result, a new specialty has emerged to fill the gap. Coronary heart disease vs coronary artery disease Cardio-oncology is a partnership of cardiologists and oncologists who combine their knowledge to help protect the hearts of people undergoing cancer treatment. Reversing heart disease “Being followed by a highly specialized cardiologist can benefit most people with cancer, but it is particularly important for someone who is at risk for heart disease or who already has heart disease,” says Dr. Signs of heart disease in child Mehra. Valvular heart disease icd 9 code The scope of the problem

The cardiovascular side effects that arise from cancer therapy are frightening. Coronary heart disease statistics worldwide Some chemotherapy agents cause the heart muscle to weaken soon after chemotherapy begins. Ischemic heart disease icd 9 code Novel angiogenesis inhibitors that suppress new blood vessel formation cause blood pressure to rise dramatically and may increase the risk of blood clots and heart failure. Structural heart disease Hormonal therapies can cause stroke, heart attacks, and blood clots. What are the symptoms of heart disease Other agents can trigger low blood flow to the heart (ischemia), heart attack, arrhythmias, or inflammation of the sac around the heart. Symptoms of heart disease women When a severe reaction occurs while a drug is being infused, it may be necessary to stop the treatment.

Dr. Most common form of heart disease Mehra and his cardio-oncology colleagues Dr. Congenital heart disease diagrams Anju Nohria and Dr. Ischemic heart disease is a condition in which Javid Moslehi at Brigham and Women’s, along with oncologists at the Dana-Farber Cancer Center, are leading an effort to learn more about the effects of anticancer agents on the heart and cardiovascular system. Is coronary heart disease the same as cardiovascular disease While the oncologists test anticancer agents in clinical trials, the scientists are investigating the effects of these agents on the heart before the agents are released for widespread use, and the cardio-oncologists are searching for ways to counteract these effects. Ischemic heart disease causes On the flip side

In addition to preventing heart disease in people undergoing cancer therapy, it is equally important to understand the impact of chemotherapy on people with heart disease and their medications.

Some angiogenesis inhibitors may render clopidogrel (Plavix) less effective. Smoking and heart disease People using blood thinners may experience excessive bleeding when their platelet counts fall as a result of cancer treatment.

Certain chemotherapy agents may interact with warfarin (Coumadin), making it less effective in preventing blood clots. Coronary heart disease case study Statins may render chemotherapy more potent and, therefore, more toxic.

The toxic properties of chemotherapy may decrease the ability of a person with a bacterial heart-valve infection to fight that infection, often with serious or fatal results.

These are areas where the cardio-oncologist can offer valuable advice that allows both diseases to be treated simultaneously and safely. Obesity heart disease Radiation woes

Radiation therapy can induce heart disease if any part of the heart is exposed to radiation. Heart disease cancer Problems can occur several years after exposure and include accelerated coronary artery disease, stiffening of the heart muscle, inflammation and thickening of the pericardial sac, problems with electrical conduction, or damage to heart valves. Women heart disease Researchers at Brigham and Women’s Hospital are now studying the potential of statins to protect against radiation-induced heart disease.

Radiation-induced heart failure is treated according to the same protocols recommended for people who develop the condition following a heart attack. Ischemic heart disease treatment Heart-protection strategies

In order to start treatment before irreversible heart damage occurs, individuals undergoing cancer therapy should be followed with appropriate screening tests. Carcinoid heart disease Drs. Ischemic heart disease hereditary Mehra, Moslehi, and Nohria are currently evaluating the use of echocardiography, electrocardiography, and certain biomarkers for identifying trouble before symptoms appear.

There is encouraging news that some forms of heart disease triggered by antitumor therapy may be reversible. Congenital heart disease screening Recently, Dr. Signs of heart disease in men Moslehi and two colleagues reported cardiomyopathy from angiogenesis inhibitors that was reversed with common heart medications.

Ultimately, the prevention of heart problems from cancer therapy is the goal. Congestive heart failure disease Here, too, there are signs of hope. Congenital heart disease statistics In 2011, British researchers were able to prevent heart failure from trastuzumab (Herceptin) using beta blockers.

“This suggests that all is not lost. Heart disease symptoms in men However, it takes a partnership and teamwork to make the right decisions,” says Dr. Ischemic heart disease ppt Mehra.

“If you are having any type of cancer therapy, its impact on your heart should be considered. Coronary heart disease uk Ask your oncologist and radiation oncologist to add a cardio-oncologist—or if one is not available, a cardiologist—to your treatment planning team.”

A partial list of chemotherapy agents with cardiovascular effects

Severe hypertension, heart failure, cardiomyopathy, thromboembolism

Severe hypertension, ischemia, atrial fibrillation, thromboembolism

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