Carcinoid heart disease

Carcinoid tumors are rare, arising in 1.2 to 2.1 per 100,000 people in the general population per year [ 1]. Symptoms of heart disease in women They can arise anywhere in the body, but are most commonly found in the gastrointestinal tract (midgut carcinoids) and bronchus (foregut carcinoids) ( table 1). Ischemic heart disease pathophysiology Primary midgut carcinoid tumors metastasize to the liver or regional lymph nodes and may present with bowel obstruction. Coronary heart disease treatment guidelines In 20 to 30 percent of patients, the initial presentation occurs as a result of hormone production, called the carcinoid syndrome. Is heart disease the same as cardiovascular disease (See “Clinical characteristics of carcinoid tumors”.)

The most common manifestations of the carcinoid syndrome are vasomotor changes (flushing) ( picture 1), gastrointestinal hypermotility (secretory diarrhea), bronchospasm, and hypotension ( table 2). Tests for heart disease These symptoms are caused by the release of vasoactive substances, including serotonin (5-hydroxytryptamine), 5-hydroxytryptophan, histamine, bradykinin, tachykinins, and prostaglandins ( table 3). Heart disease and treatment The diagnosis of carcinoid syndrome is usually suspected by the clinical features and confirmed by identification of the primary tumor, localization of metastatic lesions, and detection of increased urinary excretion of the by-product of serotonin metabolism, 5-hydroxyindoleacetic acid (5-HIAA) ( figure 1). Heart disease effects (See “Clinical features of the carcinoid syndrome” and “Diagnosis of the carcinoid syndrome and tumor localization”.)

Progress in the medical and surgical management of patients with carcinoid disease has resulted in improved symptoms and survival. Heart disease treatment (See “Staging, treatment, and posttreatment surveillance of nonmetastatic, well-differentiated gastrointestinal tract neuroendocrine (carcinoid) tumors”.)

However, carcinoid heart disease, which eventually occurs in over 50 percent of patients with carcinoid syndrome and may be the initial presentation of carcinoid disease in as many as 20 percent of patients [ 2,3], remains a major cause of morbidity and mortality among patients with carcinoid syndrome [ 4,5].

Pathologic findings — Carcinoid heart disease is characterized by pathognomonic plaque-like deposits of fibrous tissue. What does heart disease do These deposits occur most commonly on the endocardium of valvular cusps, leaflets, papillary muscles and cords, cardiac chambers, and occasionally on the intima of the pulmonary arteries or aorta ( figure 2) [ 6,7].

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Rheumatic heart disease treatment and prevention Always seek the advice of your own physician or

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