Decreasing cocaine use leads to regression of coronary artery disease

People who use cocaine regularly are at high risk of coronary artery disease. Blood veins and arteries A study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM), reports that stopping or reducing cocaine use can potentially reverse the process of coronary atherosclerosis.

In particular, reducing cocaine use leads to regression of unstable, noncalcified coronary plaques—the type most likely to cause a heart attack or stroke, according to the new research by Dr. Arteries and veins anatomy Shenghan Lai of Johns Hopkins School of Medicine, Baltimore, and colleagues. Veins and arteries quiz “In the past, there has been excellent work to uncover the consequences of drug use,” Dr. Walls of arteries and veins Lai comments.

Pictures of arteries veins and capillaries “However, few studies have revealed what happens after drug use stops. Difference between pulmonary arteries and pulmonary veins Studies of this kind give people hope for a healthier life after stopping drug use.”

Reducing Cocaine Use Leads to Improvement in Coronary Disease

Since 2000, the researchers have been studying the development of coronary atherosclerosis (“hardening of the arteries”) in more than 700 African-American patients with cocaine use. Similarities between arteries and veins Previous studies have found that a cash incentive program helps patients to stop using cocaine, or to use it less often. Difference between capillaries veins and arteries In addition, reducing cocaine use led to decreased levels of endothelin-1 (ET-1)—an inflammation-promoting protein that plays a key role in the development of coronary artery disease.

Could the drop in ET-1 lead to reductions in cocaine-induced coronary artery disease? Dr. Distinguish between arteries and veins Lai and colleagues performed a follow-up study in 15 patients with cocaine use for an average of 20 years and atherosclerosis causing more than 50 percent blockage of the coronary arteries. Arteries and veins of the body quiz Using imaging scans (CT angiography), the researchers assessed the amount and types of coronary plaques, before and after reductions in cocaine use.

As previously reported, the incentive program helped participants reduce their cocaine use: from every day before the program to an average of 50 days during one year of follow-up. Capillaries arteries and veins Levels of ET-1 and other markers of inflammation decreased as well.

Decreased cocaine use was followed by regression of atherosclerotic plaques in the coronary arteries. Learning arteries and veins The reduction was significant not only for total coronary plaques, but also for noncalcified plaques—the first step in the development of coronary atherosclerosis. Characteristics of veins and arteries Noncalcified plaques are considered unstable or “vulnerable.” Compared to calcified plaques that develop later, they are more likely to rupture and cause heart attack or stroke.

The reductions in coronary plaque remained significant after adjustment for other cardiovascular risk factors. Layers of veins and arteries Coronary artery disease regressed even though the patients were not taking cholesterol-lowering “statin” drugs.

Over the long-term, cocaine use is associated with a high risk of premature atherosclerosis. Major systemic arteries and veins of the body Cocaine use remains epidemic in the United States—a 2013 report suggested that there are 1.5 million Americans, or about 0.6 percent of the population, who use cocaine.

“This preliminary study demonstrates potentially beneficial effects of cocaine abstinence/reduction on inflammation and coronary plaque phenotype,” Dr. What structural differences did you notice between arteries and veins Lai and coauthors write. What are veins and arteries While it is unclear how reduced cocaine use leads to regression of coronary artery disease, “Inflammation appears to be a significant link.”

If confirmed by further research, such as a clinical trial, “The findings…may have important implications for the prevention of cocaine-induced coronary artery disease,” the researchers conclude. Arteries and veins of the leg Since many of the participants were also HIV-positive, the study might also be relevant to people with HIV infection, in whom coronary artery disease is prevalent.

Explore further: Stopping or reducing cocaine use associated with lower cardiovascular risk marker levels

Veit Sandfort et al. Arteries and veins Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses, Journal of Addiction Medicine (2017). What is the function of arteries and veins DOI: 10.1097/ADM.0000000000000282

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