Jonathan pitre battles blood, lung infections before second stem cell transplant

Jonathan Pitre is back in a Minneapolis hospital with blood and lung infections — complications that will likely delay his second stem-cell transplant.

Pitre and his mother, Tina Boileau, went to the University of Minnesota Masonic Children’s Hospital last week for a check-up in preparation for the transplant, scheduled for March 8.

Tests revealed that Pitre had unusually low oxygen levels in his blood. Bone marrow transplant immunosuppression Further investigation found that he had a respiratory virus and a bloodstream infection, likely caused by his surgically implanted central lines. Bone marrow biopsy needle size The thin plastic tubes, used to deliver medicine, nutrition, blood and stem cells, are susceptible to infection.


Pitre, 16, has been in hospital for the past five days. Different types of bone marrow He’s on antibiotics and is using an oxygen mask to help him breathe at night.

“He’s getting better,” Boileau said in an interview Tuesday. Bone marrow transplant prognosis “But we have to make sure the blood infection doesn’t come back. Bone marrow donation age limit We’re taking it day by day. Complications of bone marrow aspiration He’s feeling better than he did, but there’s more progress to be made, for sure.”

Doctors want Pitre to overcome the infections before they begin a second blood and marrow transplant procedure.

The Minneapolis children’s hospital is the only facility in the world that operates an ongoing clinical trial to treat severe cases of epidermolysis bullosa (EB) with stem cells. Bone marrow in bloodstream The treatment holds the potential to halt the advance of Pitre’s rare and deadly form of the skin disease, recessive dystrophic EB.

People with RDEB have a fault in the gene responsible for a specific kind of collagen that connects the outer layer of skin, the epidermis, with those below it. Bone marrow donor process The clinical trial seeks a “biochemical correction” to that fault. Is bone marrow good for you If the transplant works, stem cells will find their way to Pitre’s bone marrow, dispatch cells to his injured skin, and secrete a protein that’s essential to the development of collagen — the “glue” that gives skin its strength and structure.

Some EB patients have experienced dramatic benefits after their transplants: reduced blistering, tougher skin, and better wound healing. Transplantation of bone marrow But the transplant is high-risk and is usually accompanied by life-threatening complications.

Pitre will undergo eight days of high-dose chemotherapy and one day of full-body radiation in advance of the stem cell transplant. Bone marrow transplant hurt His mother will again serve as his donor.

Last year’s procedure failed when Pitre’s own stem cells recolonized his bone marrow.

Boileau said even though everyone knows exactly what to expect this time, it doesn’t make the journey easier to face. Where does bone marrow come from “There’s a different kind of stress this time,” she said. What is produced in the red bone marrow “It’s not the unknown this time, it’s the known — and the known is scary because it was tough.”

Pitre suffered infections, fevers, nausea and exhaustion in the aftermath of his transplant last September.

Pitre and his mother spent five weeks at home in Russell earlier this year and returned to Minnesota last week. Bone marrow cancer Boileau said her son is ready to face his next challenge. Bone marrow transplant “When he got in the truck, he said it was time to go back,” said Boileau. Bone marrow transplant guidelines “He wants to get it done so we can go home for real next time…We know we’re good to do this and we’ll come back.”

OHIP will finance the $1 million hospital procedure, while Boileau will be paying her own living expenses with the help of the EB charity, DEBRA Canada.

Jonathan Pitre is back in a Minneapolis hospital with blood and lung infections — complications that will likely delay his second stem-cell transplant.

Pitre and his mother, Tina Boileau, went to the University of Minnesota Masonic Children’s Hospital last week for a check-up in preparation for the transplant, scheduled for March 8.

Tests revealed that Pitre had unusually low oxygen levels in his blood. Bone marrow transplant patients receive Further investigation found that he had a respiratory virus and a bloodstream infection, likely caused by his surgically implanted central lines. Structure of bone marrow The thin plastic tubes, used to deliver medicine, nutrition, blood and stem cells, are susceptible to infection.

Pitre, 16, has been in hospital for the past five days. Where is the red bone marrow located He’s on antibiotics and is using an oxygen mask to help him breathe at night.

“He’s getting better,” Boileau said in an interview Tuesday. Bone marrow transplant donor pain “But we have to make sure the blood infection doesn’t come back. Red blood cells bone marrow We’re taking it day by day. What are bone marrow He’s fe

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