Overexpressed tgf-? in subchondral bone leads to mandibular condyle degradation – dec 05, 2013

Emerging evidence has implied that subchondral bone plays an important role during osteoarthritis (OA) pathology. Where is bone marrow located This study was undertaken to investigate whether abnormalities of the condylar subchondral bone lead to temporomandibular joint (TMJ) OA. Bone marrow donation stories We used an osteoblast-specific mutant TGF-?1 transgenic mouse, the CED mouse, in which high levels of active TGF-?1 occur in bone marrow, leading to abnormal bone remodeling. Bone marrow is where Subchondral bone changes in the mandibular condyles were investigated by micro-CT, and alterations in TMJ condyles were confirmed by histopathological and immunohistochemical analysis. Blood cancer bone marrow Abnormalities in the condylar subchondral bone, characterized as fluctuant bone mineral density and microstructure and increased but uncoupled activity of osteoclasts and osteoblasts, were apparent in the 1- and 4-month CED mouse groups, while obvious cartilage degradation, in the form of cell-free regions and proteoglycan loss, was observed in the 4-month CED group.


Bone marrow biopsy video In addition, increased numbers of apoptotic chondrocytes and MMP9- and VEGF-positive chondrocytes were observed in the condylar cartilage in the 4-month CED group, but not in the 1-month CED group, compared with their respective age-matched controls. Bone marrow transplant cancer This study demonstrated that progressive degradation of mandibular condylar cartilage could be induced by the abnormal remodeling of the underlying subchondral bone during TMJOA progression.

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K. Where do you find yellow bone marrow Jiao 1 , M. Bone marrow cancer symptoms nhs Zhang 1 , L. Bone marrow biopsy scar Niu 2 , S. Bone marrow transplant recovery Yu 1 , G. National bone marrow registry Zhen 3 , L. Bone marrow cancer how long to live Xian 3 , B. Bone marrow transplant needle Yu 3 , K. Bone marrow biopsy contraindications Yang 4 , P. How to take bone marrow Liu 5 , X. Lymphoma bone marrow Cao 3 , M. Stem cells from bone marrow Wang 1 * 1Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi’an, 710032, China 2Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi’an, 710032, China 3Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 4Department of Immunology, Fourth Military Medical University, Changle Western Road No.17, Xi’an, 710032, China 5The State Lab of Oral Disease, Huaxi Dental School, Sichuang University, Chengdu, China

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