Utility of autologus bone marrow stem cells for treatment of chronic leg ulcer _ omics international

Utility of autologus bone marrow stem cells for treatment of chronic leg ulcer 3 rd International Conference and Exhibition on Cell & Gene Therapy

October 27-29, 2014 Embassy Suites Las Vegas, USA Said M H Abdou

Chronic leg ulcer is a major health problem which may associate different diseases as vascular, neoplastic, infectious

diseases and trauma as well. Blood in bone marrow The patients suffer from many complications as infection, septicemia, psychology troubles

and physical inability leading to many economic troubles the last line of treatment is amputation with its high rate of morbidity

and mortality. Bone marrow donor register Optimum healing of a cutaneous wound requires a well-orchestrated integration of the complex biological and

molecular events of cell migration and proliferation, and of extracellular matrix deposition and remodeling. Bone marrow transplant blood type Several studies

in recent years suggest that bone marrow derived stem cells such as hematopoietic stem cells cell progenitors, mesenchymal

stem cells, multi-potent stem cells, progenitor cells such as endothelial progenitor cells and fibrocytes may be involved in these

processes, contributing to skin cells or releasing regulatory cytokines.


Bone marrow blood Progenitor cells such as endothelial progenitor cells and

fibrocytes may be involved in these processes, contributing to skin cells or releasing regulatory cytokines. Bone marrow donor eligibility Direct injection of

bone marrow derived CD34 positive cells, mesenchymal stem cells or endothelial progenitor cells into injured tissues shows

improved repair through mechanisms of differentiation and/or release of paracrine factors. Donating bone marrow Enhanced understanding of these

cells may help develop novel therapies for difficult cutaneous conditions such as non-healing chronic ulcers and hypertrophic

Aim of the work: The study design was randomized clinical trial attempt to assess the potential treatment of chronic leg ulcer

Patients and methods: Fifty patients with chronic leg ulcer were included from vascular surgery department Tanta University

Hospital. Treatment of bone marrow cancer Patients were divided randomly into two equal groups each group included 25 patients. Lymphoma bone marrow transplant In group I, the patients were

subjected to autologous transplantation of bone marrow derived CD34+ mononuclear cells into the depth and around the

ulcer. Allogeneic bone marrow In group II (control group), saline dressing to the leg ulcer was done.

Results: In group I, 14 patients were males and 11 were females, age ranged from 19 to 66 years with mean age of 48.7 y while

in group II, 13 patients were males and 12 patients were males with mean age of 51.2 years and age ranged from 21 to 63 years.

In group I, the follow up period ranged from 6 to 24 months. Marrow of the bone Complete ulcer healing occurred in 12 patients (48%), partial

ulcer healing in 10 patients (40%) and no healing in 3 patients (12%). Donating bone marrow procedure In group II, the follow up period ranged from 8 to 24

months. Bone marrow blood production Complete ulcer healing occurred in 2 patients (8%), partial ulcer healing in 3 patients (12%) and no healing in 20

patients (80%). Red bone marrow and yellow bone marrow In group I, the overall patients satisfaction and pain relief was found in 18 patients (72%) while in group II only

Conclusion: Autologous transplantation of bone marrow derived CD 34+ mononuclear cells is a simple, safe and effective

Said M H Abdou is the Professor of Clinical Pathology, Department of Clinical Pathology, Faculty of Medicine, Tanta University. Bone marrow transplant for cancer He is leading a group working on

preclinical and clinical trials on the utility of stem cells in treatment of chronic leg ulcer and chronic leg ischemia. Bone marrow transplant list His team also focuses on the use of stem cell

based therapy for treatment of end stage liver disease, alopecia areata and treatment of chronic obstructive lung disease. Stem cell and bone marrow transplant His lab activities during the last 10 years

have been dealing with examination of all types of biological human samples hematology and biochemistry to help diagnosis and treatment of patient’s diseases

including genetic disorders. Red bone marrow function He is collaborating with several national and international researchers focusing on the utilization of stem cells for therapy against leg

ischemia in animal models as well as against cancer immunotherapy.

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